Emma Mhic Mhathuna has died from cervical cancer aged 37.
The mother of five was diagnosed with the disease in 2016, having received two incorrect smear results.
In May, she settled her case in the High court against the HSE and the US laboratory, Quest Diagnostics for 7.5 million euro.
Quest admitted to misreading two cervical smear tests in 2010 and 2013.
The HSE admitted liability for not disclosing the findings of the CervicalCheck audit.
The 37 year old is survived by her five children.
Tributes have been paid to her from the Taoiseach, President and Minister for Health - along with advocacy groups across the country.
Very sad to hear of Emma Mhic Mhathúna’s passing. She showed incredible bravery in fighting a terrible disease. Thoughts with her family on this dreadful loss. We must beat this cancer with vaccination & screening. We are determined to build a programme worthy of women like Emma
— Simon Harris TD (@SimonHarrisTD) October 7, 2018
May you rest in peace now Emma. My thoughts are with your children who should not have to be facing into a future without you Xxx #EmmaMhicMhathúna
— Vicky Phelan (@PhelanVicky) October 7, 2018
Very sad news today. Emma Mhic Mhathúna's bravery in the face of so much tragedy has inspired many people. Her legacy and strength will impact on cancer healthcare for the better. Our thoughts and prayers are with her family and 5 children. Rest In Peace.
— Simon Coveney (@simoncoveney) October 7, 2018