Facebook's suffered a blow - as the co-founders of Instagram quit to 'build new things'.
Kevin Systrom and Mike Krieger have issued a statement saying they want to 'explore our curiosity again'.
They'll step down in the next few weeks - six years after Facebook snapped up the photo-sharing app.
Mr Systrom - who is also Instagram's CEO - added: "We remain excited for the future of Instagram and Facebook in the coming years as we transition from leaders to two users in a billion.
"We look forward to watching what these innovative and extraordinary companies do next."
Over 8 years ago, Kevin and I started Instagram, hoping to build something that would bring out people’s creativity and spirit for exploration. Now it’s time for the next chapter. A huge thank you to everyone in the community who we’ve met along the way. https://t.co/9Omyj6VHbe
— Mike Krieger (@mikeyk) September 25, 2018
Facebook CEO Mark Zuckerberg wished the two men well, adding: "I'm looking forward to seeing what they build next."
The Instagram founders are not the first high-profile executives to leave a popular company acquired by Facebook - the founders of messaging app WhatsApp also quit amid reports of disagreements with Facebook.