The Department of Health's Chief Medical Officer Dr Tony Holohan will return to his post next week.
Holohan had become a well-known figure during the early stages of the COVID-19 pandemic, as he recommended strict measures to tackle the virus including the national lockdown.
However, he stepped back from his role in July as his wife was receiving palliative care.
Dr. Ronan Glynn has been working as the Acting Chief Medical Officer since then.
Health Minister Stephen Donnelly says he's looking forward to working with Dr Holohan.
Minister Donnelly said "Dr Holohan has done an extraordinary job" while also acknowledging that Dr ROnan Glynn has done "incredibly well in stepping into that role" in recent months.