Coalition party leaders are meeting this evening, and a cabinet meeting is taking place tomorrow on whether the mask mandate should end.
The public has been encouraged to wear masks if they wish to feel comfortable once restrictions are removed.
It's expected they will follow NPHET recommendations to scrap the requirement for face masks to be mandatory in areas like schools, shops and public transport.
Social protection minister Heather Humphreys says the government will follow the official advice.
"Yeah well I understand that some people are nervous and for those I would encourage those to continue to wear a masks if you feel more comfortable wearing a mask and people should respect that decision.
"We have always follow the NPHET advice in fairness and I think that we should go with that advice and I think the Taoiseach has made that clear as well."
Professor of Immunology at DCU is Christine Loscher - she believes there's a more natural conclusion to the mask mandate at the end of March.
"We would generally see that during March we would see drops in case numbers of viruses in general, as the weather improves and people start to move outdoors.
"I would think there's more of a natural point of easing off on that mitigation factor of masks more towards the end of March."