With Tryone not having won an All-Ireland Senior Football final in ten years and Dublin going for 4-in-a-row, this Sunday's clash is a tale of two very different sides.
To see how they match-up, Offtheball.com's sports sensei Darren Cleary popped by for a chat with Dermot and Dave.
The lads discuss the effect 'home advantage' has on the game, explore the ways Tyrone can learn from earlier mistakes this season (and possibly take the 'boys in blue') and are baffled how Tyrone got to the final in the first place (due to the new system in place).
But it's like Darren says at the beginning of the chat, "it's hard be humble and a Dub nowadays" - they are a well-oiled machine!!
Still, I'll have my red hand raised high in hope. I am a Mayo man afterall #Mayo4Jam
Michael Lyster and co. will be live on RTÉ2 from Croke Park for all the build-up from 2.30pm. Throw-in is 3.30pm.
Check out the discussion in full by pressing the play button in the image at the top of the page.