An average of seven people dies every week from a drug overdose, according to a new report.
That's around one person a day, meaning 12 people will die from a drug overdose before Christmas.
The Health Research Board says there were a total of 376 deaths due to poisoning in 2017.
Alcohol was a factor in a third of the cases, while heroin contributed to 77 deaths.
The report also shows that cocaine deaths rose by 26 percent in the space of one year.
53 of those related to cocaine overdoses - up from 42 the previous year.
Speaking about the newly released figures, HRB researcher Ena Lynn said many people lose their lives after taking a combination of substances.
She explained: "We see that people taking cocktails of drugs contribute to three in five of our poison deaths in 2017.
Ms Lynn also suggested the increase in cocaine-related overdoses is linked to Ireland's improving financial situation.
She said: "We see it mirrors our economy in Ireland - we saw it peaking in 2007, followed by a decline.
"Unfortunately, similar to our economy, we've seen an increase in cocaine-related deaths since 2010."