160 jobs are to go at the MBNA call centre in Co Leitrim.
The operation in Carrick-on-Shannon is to close at the end of November.
The call centre provides support to the credit card company's UK customer base.
The Jobs Minister Richard Bruton, pictured above, says every support will be offered to the workers.
The 250 employees at Advent Apollo in Carrick-on-Shannon, former MBNA staff, are not affected.
Our News Correspondent Fergal O'Brien reports:Local people have been telling Shannonside FM that the job losses represent a huge blow to Carrick-on-Shannon:
