340 new jobs have been announced at separate companies in Cork, Dublin and Limerick.
140 positions are being created at GE Healthcare in Carrigtwohill.
The company plans to double existing production capacity at it's East Cork operation.
Meanwhile, 100 new positions are being created at digital communications company, Neopost in Citywest in Dublin.
The positions are in management, finance, IT, telesales and administration.
And 100 new jobs are on the way at a new engineering and pharmacy campus at the Limerick Institute of Technology.
143 temporary positions will also be rolled out during the construction phase.