The Department of Foreign Affairs says four Irish citizens who are believed to have been in Nepal at the time of the earthquake have yet to make contact.
Foreign Affairs Minister Charlie Flanagan says some of these people may be in remote areas where communications are sporadic.
He says there are no suggestions at this stage of any Irish fatalities.
One injured Irish citizen was successfully evacuated on a Norwegian flight this morning, following contacts between the Department and Norwegian counterparts overnight.
The number of dead from the Nepal earthquake has passed 5,000.
Nepalese riot police have been deployed to hold back thousands of residents trying to leave Kathmandu.
Many are angry at the lack of help being given.
A massive avalanche hit a Mount Everest base camp after the quake.
Climber Jost Kobusch captured the moment on video - which has since gone viral.