The HSE is urging anyone who wants a booster to come forward this week if possible.
It's estimated up to 220,000 doses will have to binned by the end of the month, as they're due to expire.
Head of the Vaccination Programme Damien McCallion says once vaccines are sent out to GPs, mass vaccination centres and pharmacies, they have a 30-day shelf life.
"So we're really encouraging people this week - make a late New Year's resolution and get a booster.
"You can book a time to suit you in the vaccination centres, and GPs have agreed to take patients other than their own."
The high case numbers over Christmas means many people now have to wait three months to get a booster, which is contributing to the issue of vaccines going to waste.
Chair of the GP committee of the IMO Dr Denis McCauley says reducing the time to one month wouldn't be an effective solution.
"The immune response you get really means there's no need for the booster at a month.
"It may use up the vaccines but is an appropriate thing to do from a medical point of view?"
Dr McAuley also says there's unlikely enough time left to send the doses broad, before they expire.