US President Barack Obama and Cuban President Raul Castro have met on the fringes of the summit of the Americas.
It's the first formal talks between the two countries' leaders in half a century.
It's reported Barack Obama says the US is ready to "turn the page" with Cuba - but that significant differences remain.
Earlier, Mr Obama described the historic thaw in US-Cuba relations as a "turning point".
Mr Castro has called for the lifting of the US economic blockade on Cuba, in place since 1959.