Merchants Quay Ireland says it helped an extra 2,000 intravenous drug users in 2012 compared to the previous year.
Its annual review shows homelessness and drug use are on the rise, with three and half thousand people accessing it's needle exchange last year.
500 of these were first time drug users.
The MQI homeless food service provoided over 76, 500 meals in 2012 and the primary healthcare service for homeless people made 3,316 individual clent interventions.
Cheif Executive Tony Geoghan says the statistics are a strong indication of the increasing levels of poverty and harship experienced by so many people.
There was also growth in drug use outside Dublin with MQI's Midland Harm Reduction Outreach Service woking with an average of 130 clients per month providing over 3,000 needle exchange interventions during the year.
Tony Geoghan says in Dublin alone there are at least 100 people sleeping rough on our streets every night.
He spoke to Sinead Spain.