A man in his 20s died after his car collided with a lorry at Bawnard, Ardmore at around 4:30am this morning.
He was pronounced dead at the scene.
The man driving the lorry, who is in his late 40s, was taken to University Hospital Waterford where his injuries are described as non life threatening.
The stretch of road is currently closed to facilitate an examination by Garda Forensic Collision Investigators and local diversions are in place.
Gardaí are appealing for witnesses who were on the N25 between the hours of 4am and 5am from Youghal bridge to Dungarvan and who may have dash cam footage to contact them at Dungarvan Garda Station on 058 - 48600, The Garda Confidential Line 1800 666 111 or any Garda Station.