It took over four hours for an ambulance to arrive at a life-threatening emergency call, 94 times last year.
According to freedom of information figures, 21 were over five hours.
The HSE aims to respond to life-threatening heart and respiratory calls within 18 minutes and 59 seconds in 80% of cases.
Other life-threatening emergencies should be responded to within the same timeframe in 50% of cases.
On almost 6,200 occasions last year, it took over an hour for an ambulance to respond to either of these types of calls.
The longest was almost 7 hours and 10 minutes to a call in Waterford.
That was followed by over 6 hours of calls in Cork and Westmeath.
A total of 233 response times were over 3 hours.
The Oireachtas health committee will discuss ambulance services, including response times, with the National Ambulance Service and Dublin Fire Brigade this morning.
