Nine Palestinians have been killed and hundreds injured in clashes with Israeli forces.
Protesters burned tyres as they demonstrated along the border with Israel, with some demonstrators throwing stones.
Israeli forces fired tear gas and live rounds in response to what they described as 'rioting'.
According to officials in Gaza, journalist Yasser Murtaga and a 16-year-old boy were among those killed.
Dozens of children are reported to be among those injured.
Palestinians protest along the barrier between Gaza and Israel near Nahal Oz. Picture by: JINI/Xinhua News Agency/PA Images
Israeli Defence Forces claimed: "Hamas is burning tires to make a smokescreen and using it in an attempt to turn the Gaza-Israel border into a warzone."
Over the past hour, rioters have attempted to damage & cross the security fence under the cover of smoke from their burning tires. They also attempted to carry out terror attacks & hurl of explosive devices & firebombs pic.twitter.com/g8fk9N4vcT
— IDF (@IDFSpokesperson) April 6, 2018
17 people died after a similar protest last Friday.
Palestinians in Gaza are staging a six-week stretch of demonstrations, with protesters calling for refugees to be allowed return to their ancestral homes in what is now Israel.
