A Tipperary meat processing plant says it's been forced to lay off 355 workers due to the ongoing blockade at its site.
ABP Foods in Cahir says a further 182 jobs may be impacted by the end of the week.
In a statement, ABP says: 'This regrettable action is a direct result of the ongoing illegal blockades at the site. The protestors have stopped any product going in to or leaving the site. Production has ceased. Furthermore, these illegal blockades are impacting seriously on the thousands of beef farmers who supply cattle to the site.'
Farming organisations widely supported recommendations made at the weekend following marathon talks.
However many farmers - who are unhappy with the deal - continue to protest at factories.
Meanwhile, The Minister for Agriculture has written an open letter to protesting beef farmers asking them to end their blockades at meat factories..
Micheal Creed says farmers voices have been heard 'loud and clear', but that nobody got everything they wanted from the talks.
He added that many farmers simply wanted an immediate price increase but it was not legally possible to have that option on the table.