Last year's Derby winner Anthony Van Dyck has been declared a non-runner ahead of tomorrow's King George VI And Queen Elizabeth Qipco Stakes at Ascot.
Enable, who is bidding for a third win in the race, will now face only two rivals in this year's renewal.
We weren't 100 per cent happy with Anthony Van Dyck's bloods when they came back this evening and, as a result, we're not going to run him at Ascot tomorrow," trainer Aidan O'Brien told The Racing Post.
"It's disappointing but we have to do the right thing by the horse."
The Ballydoyle supremo will still run Sovereign and Japan tomorrow with Ryan Moore booked to ride the latter:
"We're very happy with Japan - everything about his first two runs this season was leading into the King George.
"The first day at Ascot, he got upset in the stalls and missed the break, then he got a little tired, but we were happy.
"We were delighted with him at Sandown in the Eclipse and we felt he would progress big time for it.
"Everything about his work since has been very good, and we are where we hoped he would be.
"It will be Enable and Frankie Dettori and Japan and Ryan Moore - so it will be some spectacle. The two horses and the two lads, we're looking forward to it."