A minimum of four positive Covid-19 cases in a squad is now the threshold for a Premier League match to be postponed.
The Premier League has moved to change the guidelines in place, which had been the subject of some complaints from clubs.
Previously, clubs had to prove they had less than 13 available outfield players, plus a goalkeeper, for a given fixture.
Under those rules, a total of 22 top-flight matches were postponed.
However, following a meeting of clubs today, there has been a change in the requirements.
From now on, if a club applies to postpone a match on the grounds of insufficient players due to COVID-19, they must have a minimum of four positive cases within their squad
— Premier League (@premierleague) January 26, 2022
There was controversy when Arsenal's north London derby clash with Tottenham was postponed last week.
It's understood Arsenal had just one positive case within their squad, which prompted a re-think on the rules.
Premier League statement
"From now on, if a club applies to postpone a match on the grounds of insufficient players due to COVID-19, they must have a minimum of four positive cases within their squad," a Premier League statement read.
"This guidance will come into effect ahead of the next Premier League fixture on Saturday 5 February (Burnley FC v Watford FC).
"Throughout the pandemic, the Premier League has adapted its guidance in response to the wider public health situation.
"The guidance was last updated in December in response to the emergence of the Omicron variant.
"The League’s postponement rules and guidance are designed to protect the wellbeing of players and staff, while maintaining the sporting integrity of the competition and the quality of squads playing League matches.
"Club applications will continue to be assessed on a case-by-case basis.
"The Premier League Board examines a number of factors, including the ability of a club to field a team; the status, severity and potential impact of COVID-19; and the ability of the players to safely prepare for and play the match. The detail within all applications is scrutinised by the League’s specialist staff before the Board makes its decision."