Harry Kane has not travelled with the Tottenham squad to their Premier League game against Manchester City.
The Athletic is reporting that the striker has not been deemed fit enough to play in the game at the Tottenham Hotspur Stadium.
Jack Grealish meanwhile makes his first league start for Pep Guardiola's side.
No Kane, not able.
Back at it for another year on @offtheball with Brian Kerr, starting with a tasty one between Spurs and Man City.
Harry Kane not in the Spurs squad. pic.twitter.com/ec8yIRCGfw
— Nathan Murphy (@nathanmurf) August 15, 2021
Kane has been in the middle of a long-running saga over the summer in relation to his desire to leave the club.
City are believed to be preparing to put in a fresh bid of £127 million for the striker.
Following Kane's involvement in the European Championship with England over the summer he did not report for training when the club resumed for pre-season.
He denied that he had refused to train and carried out a five-day quarantine before returning to training last week.
New Spurs manager Nuno Espirito Santo had indicated on Friday that Kane may have featured in the game.
“He’s a Tottenham player.
"He’s here with us, we have to think about tomorrow. Let’s prepare the training session of tomorrow and go day by day.”