100 new jobs have been announced for Dublin, Galway and Cork.
The IDA says the roles are being created by five different 'high growth companies from Europe and the US'.
Payments company Total Processing plans to create 25 new jobs, while Alliance Strategies has announced 15 new marketing and finance roles in Galway.
Health technology company, Movano Health is expanding its Cork operations with 20 new jobs. Pharmaceuticals company QbDVision is also bringing 15 new jobs to Cork.
The remaining jobs will be created by software company Xenon arc when it opens a new EMEA customer support and operations office in Dublin.
Welcoming the news, Minister for Enterprise, Simon Coveney, said the range of industries and locations demonstrates "Ireland’s position as an excellent strategic choice for global business, both in terms of our geographic location and our wealth of diverse and highly skilled talent".
Mary Buckley, Interim CEO of IDA Ireland, said "I particularly welcome the locational spread of these investments which shows that the technology offers, availability of talent and attractive work-life balance resonates with overseas investors.”