The Taoiseach has said he has total confidence in Health Minister Simon Harris.
It comes as documents show Minister Harris was aware of a possible 400 million euro overrun at the National Children's Hospital in August last year, 7 weeks before he told the Taoiseach or the Finance Minister.
Leo Varadkar has said concerns about the impact on budget planning are a red herring - as capital expenditure was decided last February.
The Taoiseach said even if Simon Harris had told him about the overruns earlier, he would have instructed him to do exactly what he did.
Sinn Fein say the Minister's position is untenable and are calling for him to be removed from office.
Fianna Fail TD Sean Fleming also says he believes Simon Harris should resign as Health Minister.
Labour's health spokesperson Alan Kelly thinks the issue raises questions about the future of the government.
Speaking on the Last Word on Today FM Kelly also took aim at the Minister for Finance:
If there's a motion of no confidence in Harris or Paschal Donohoe we will be supporting it.
I believe Paschal Donohoe has a lot more answers to give on this than are being given.