A man's risk of developing cancer is almost 25% higher than a women's, while their risk of death from cancer is over 30% higher.
Figures from The National Cancer Registry's annual report show 43,000 cancers were diagnosed here each year between 2017 and 2019 - with 24,000 of those invasive cancers.
They also show that over 12,700 men are diagnosed each year with invasive cancer, compared to 11,000 women, with lung cancer being the leading cause of cancer deaths.
The disease remains the most common cause of death despite improved survival rates, with lung cancer accounting for the highest number of cancer deaths in both men and women.
"These figures could not be clearer," said Donal Buggy, head of services with the Irish Cancer Society.
"Men in Ireland are much more likely to get, and die from, cancer. An estimated 12,769 males are diagnosed with an invasive cancer each year, compared to just over 11,000 for women.
"When adjustments for age are made, this means an increased risk of getting cancer of almost a quarter. If we look at mortality, the numbers are even more worrying.
"The report states that the risk of dying from cancer was about 32% higher for men than for women. It is vital that we all take collective action on it.
"Men's health needs a renewed focus and funding by the State for cancer prevention programmes. We also need further research into what the barriers are for men when it comes to choosing healthy behaviours or accessing healthcare and screening."