Johnny Sexton will reach the milestone of 100 international caps for Ireland on Saturday.
The Leinster out-half has been handed a starting berth by head coach Andy Farrell for the clash with Japan.
Sexton also captains the side.
He'll be partnered at half back by Jamison Gibson Park, who starts at scrum-half ahead of Conor Murray.
In the forwards, there's a first start at loosehead for Andrew Porter.
There's also a significant milestone for Tadhg Furlong, who will win a 50th cap.
He has been playing there for Leinster since the start of the season and offers Farrell more possibilities in that area.
Saturday's game at the Aviva Stadium will be followed by the meetings with New Zealand and Argentina in the coming weeks.
The IRFU have confirmed that a number of tickets are still available for the game against Japan and are on general sale.
Ireland team vs Japan
15. Hugo Keenan (Leinster/UCD) 13 caps
14. Andrew Conway (Munster/Garryowen) 25 caps
13. Garry Ringrose (Leinster/UCD) 34 caps
12. Bundee Aki (Connacht/Galwegians) 31 caps
11. James Lowe (Leinster) 6 caps
10. Johnny Sexton (Leinster/St Mary’s College) 99 caps CAPTAIN
9. Jamison Gibson Park (Leinster) 10 caps
1. Andrew Porter (Leinster/UCD) 37 caps
2. Ronan Kelleher (Leinster/Lansdowne) 13 caps
3. Tadhg Furlong (Leinster/Clontarf) 49 caps
4. Tadhg Beirne (Munster/Lansdowne) 22 caps
5. James Ryan (Leinster/UCD) 37 caps
6. Caelan Doris (Leinster/St Mary’s College) 9 caps
7. Josh van der Flier (Leinster/UCD) 32 caps
8. Jack Conan (Leinster/Old Belvedere) 20 caps
16. Dan Sheehan (Leinster/Lansdowne)*
17. Cian Healy (Leinster/Clontarf) 109 caps
18. Finlay Bealham (Connacht/Buccaneers) 16 caps
19. Iain Henderson (Ulster/Academy) 63 caps
20. Peter O’Mahony (Munster/Cork Constitution) 76 caps
21. Conor Murray (Munster/Garryowen) 89 caps
22. Joey Carbery (Munster/Clontarf) 24 caps
23. Keith Earls (Munster/Young Munster) 93 caps