Friday night’s FA Cup third round meeting of Aston Villa and Liverpool is under threat.
Villa have closed their Bodymoor Heath training ground after "a significant" coronavirus outbreak.
They say a large number of players and staff are isolating following a number of positive results from tests conducted on Monday.
One 3rd round tie is already in need of rearranging.
Saturday's meeting of Southampton and Shrewsbury Town has been postponed. The sides were due to meet at St. Mary's.
But the League One club informed the FA of a number of positive cases in their squad - stating they don't have enough fit, non-isolating players to fulfil the fixture.
The Professional Game Board will meet next week to decide what will happen with the fixture.
Elsewhere, Derby County interim manager Wayne Rooney and his entire first-team squad will sit out their 3rd round contest with Chorley Town.
A number of Derby's first-team and staff returned positive tests for Covid-19 on Monday, with the training facilities subsequently closed.
Earlier this week, the Premier League revealed a record high of 40 positive coronavirus cases among their latest two rounds of testing.
Aston Villa can confirm that the Club has closed its Bodymoor Heath training ground after a significant Coronavirus outbreak.
A large number of first team players and staff returned positive tests after being routinely tested on Monday and immediately went into isolation.
A second round of testing was carried out immediately and produced more positive results today.
First team training ahead of tomorrow’s FA Cup match with Liverpool was cancelled.
Discussions are ongoing between medical representatives of the Club, the Football Association and the Premier League.